Welcome to Neuroscience Center Zurich

Prof. Dr. Sebastian Jessberger



Brain Research Institute / HiFo
Laboratory of Neural Plasticity
University of Zurich

Winterthurerstrasse 190
8057 Zurich

Main Goals, Keywords

New neurons are continuously generated in two discrete areas of the adult brain – the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Our group is interested in the underlying biology of adult neurogenesis, including the fate plasticity of adult neural stem cells (NSCs) and the molecular mechanisms governing stem cell activity and neuronal integration. Our projects also aim to understand the functional contribution of adult neurogenesis to normal hippocampal function and its role in neurogenesis-associated diseases such as major depression, ageing, and epilepsy.

Group Members

1 professor, 5 postdoc, 3 graduate students

Previous, Current and Future Research

The finding that new neurons are continuously born in the adult brain has challenged traditional concepts of brain plasticity. Our efforts are focused on several aspects of adult neurogenesis (please check also for details)

Techniques and Equipment

Standard protocols in cell and molecular biology. Lenti- and retroviral techniques. Steretotactic intracerebral injections. Primary neural and NSCs cultures. Adult hippocampal slice cultures. Transgenesis.

Selected Publications


Swiss National Science Fondation, NCCR Neural Plasticity and Repair, EMBO, HFSP



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