Prof. Dr. Daniel Brandeis

 

Main Goals, Keywords

Mapping brain functions during normal development and in child and adolescent psychopathology, using multimodal imaging during tests of reading, attention and motor control (ADHD, dyslexia, development, plasticity, longitudinal studies, reading, attention, EEG, ERP, fMRI, functional brain mapping)

Group Members

1 professor, 2 postdoctoral students, 2 PhD students, 1 technician

Previous and Current Research

• Functional ERP brain mapping studies of Attention Deficit Hyperactivity Disorder (ADHD) in families: Spatiotemporal localization of deficits in attention, inhibition and motor control in ADHD children; longitudinal follow-up, genetic family study of endophenotypes (in cooperation with A. Rothenberger & T. Banaschewski, Department of Child and Adolescent Psychiatry, Göttingen)
• Functional brain mapping of Dyslexia in families: neural specialization during reading learning, reading acquistion and consolidation in children with Dyslexia, imaging of endophenotypes (EU Project Neurodys, PI G. Schulte- Koerne, with L. Blomert, Department of Psychology, Maastricht, K. Landerl & H. Wimmer, Department of Psychology, Salzburg)
• Functional brain mapping of developmental plasticity using multimodal imaging with ERP and fMRI/DTI (cooperation with the MRI Research Group, Childrens's Hospital Zürich and USZ / IBT Zurich)

Future Projects

Functional brain mapping of specific training for children and in adolescents with ADHD and Dyslexia, based on endophenotypes and genetic markers (neurofeedback in ADHD, reading training in Dyslexia)

Techniques and Equipment

Advanced EEG and ERP mapping techniques (microstates, tomography) to isolate neural networks in time and space, cognitive activation tests (attention, inhibition, language, visuomotor coordination) to selectively activate neural functions.

Shielded test room, 64 channel DC EEG amplifiers, mobile MR-compatible 64 channel EEG for simultaneous synchronized recording during fMRI, cognitive testing system (visual and auditory), 3-D digitizer, map analysis and source localization packages.

Selected Publications

• Brem, S., Bach, S., Kucian, K., Guttorm, T., Martin, E., Lyytinen, H., Brandeis, D., & Richardson, U. Brain sensitivity to print emerges when children learn letter speech sound correspondences. Proceedings of the National Academy of Sciences of the United States of America, 107(17), 7939-7944 (2010).
• van der Mark, S., Klaver, P., Bucher, K., Maurer, U., Schulz, E., Brem, S., Martin, E., Brandeis, D. The left occipitotemporal system in reading: Disruption of focal fMRI connectivity to left inferior frontal and inferior parietal language areas in children with dyslexia. Neuroimage Oct 7 (2010).
  
• Michels, L., Bucher, K., Lüchinger, R., Klaver, P., Martin, E., Jeanmonod, D., & Brandeis, D. Simultaneous EEG-fMRI during a working memory task: Modulations in low and high frequency bands. PLOS One 5(4), e10298 (2010).

Selected Lectures, Seminars, Colloquia

EEG Felder und Hirnfunktionen

Funding

Swiss National Science Foundation, EU

URL

http://www.uzh.ch/caps/