Welcome to Neuroscience Center Zurich

Prof. Dr. Karl Frei


Head of Research
Department of Neurosurgery
University Hospital Zurich

Frauenklinikstrasse 10
8091 Zurich

Tel. +41 44 255 2479
Fax +41 44 255 4514

Main Goals, Keywords

Our research interests lie in the field of brain tumors (therapy and interaction with the immune system) and on cellular and molecular aspects of the blood-brain barrier in various pathophysiological conditions (tumor, epilepsy and bacterial meningitis).

Keywords: Glioblastoma, blood-brain barrier, dendritic cells, epilepsy, drug resistance, bacterial meningitis, moyamoya angiopathy

Group Members

1 professor, 1 senior research fellow, 1 PhD student, 1 MD/PhD student, 2 medical doctoral students, 1 technician

Previous and Current Research

Future Projects

Techniques and Equipment

Murine models of inflammatory (bacterial and viral meningitis) and demyelinating (EAE) CNS diseases. Brain tumor model in mice and rat and expertise in microsurgery. Cell cultures of a broad range of primary mammalian cells (rat, mouse and human) and cell lines. Molecular biology (Northern blot, gene array and RT-PCR), protein biochemistry (Western blot, immunoprecipitation, ELISA) and immunohistological methods (immunohistochemistry and immunofluorescence).
CO2/O2-incubators, biohazard laminar flow benches, ultracentrifuge, centrifuges, spectrophotometer, cell harvester, microtomes (for paraffin- and cryosections), ELISA reader, inverted fluorescence microscope, Zeiss photomicroscope, lyophilisator, various blotting systems, RT-PCR machine.

Selected Publications

Selected Lectures, Seminars or Colloquia


National Center for Competence in Research (NCCR) „Neural Plasticity and Repair", Olga Mayenfisch Foundation


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© 2015 ETH Zurich | Imprint | Disclaimer | 1 May 2013