printlogo
http://www.ethz.ch/index_EN
Welcome to Neuroscience Center Zurich
 
print
  

Prof. Dr. Burkhard Becher

 

becher_b

Institute of Experimental Immunology
Department of Neuroimmunology
University of Zurich

Y44/J7 (Office), J38/42 (Lab)
Winterthurerstrasse 190
8057 Zurich

Tel. +41 44 635 3701
Fax +41 44 635 6883

becher@immunology.uzh.ch

Main Goals, Keywords

Our research aims to understand i) the development of tissue-specific autoimmunity ii) the interaction of the nervous system with the immune system under inflammatory conditions:

1) Neuroimmunology, Cytokine biology

2) Identification of pathogenic molecules specific for autoimmune T lymphocytes

3) Immune tolerance and lymphoid development

4) Anti-tumor immunity

Keywords: Autoimmunity, anti-tumor immunity, Neuroimmunology , Neuro-Immune-Networks, Antigen-Presentation, Cytokines, transgenic mice, Gene-targeting, Embryonic stem cells, EAE, MS.

Group Members

1 Professor, 1 Research Associate, 8 Post-docs, 12 PhD-Students, 1 Masterstudent

Previous and Current Research

Although the central nervous system (CNS) has been characterized as an immune privileged site, its privilege can be breached as a result of infection or of the development of anti-self reactivity. In autoimmune diseases such as multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) neuroantigen-reactive, auto-aggressive T lymphocytes escape immune tolerance mechanisms and infiltrate the CNS to cause tissue damage leading to neurologic deficit. A focus of our research is to achieve a better understanding of the events leading to autoimmunity and the pathogenicity of auto-reactive lymphocytes. We further aim to delineate the immune/CNS interface and the ability of CNS-resident cells to orchestrate the development of CNS inflammation.

Techniques and Equipment

In vivo immunology using gene-targeted and transgenic mice, Immune-modulation, protein biochemistry, molecular biology, in vivo bioluminescence imaging, gene-targeting and ES-cell culture.

Selected Publications

Funding

Swiss National Research Foundation, Swiss MS-Society, National MS-Society (USA), Koetser Foundation, NCCR Neural Plasticity and Repair, Merck-Serono

URL

http://www.immunology.uzh.ch/departments/neuroimmunology/research.html

 

Wichtiger Hinweis:
Diese Website wird in älteren Versionen von Netscape ohne graphische Elemente dargestellt. Die Funktionalität der Website ist aber trotzdem gewährleistet. Wenn Sie diese Website regelmässig benutzen, empfehlen wir Ihnen, auf Ihrem Computer einen aktuellen Browser zu installieren. Weitere Informationen finden Sie auf
folgender Seite.

Important Note:
The content in this site is accessible to any browser or Internet device, however, some graphics will display correctly only in the newer versions of Netscape. To get the most out of our site we suggest you upgrade to a newer browser.
More information

© 2014 ETH Zurich | Imprint | Disclaimer | 1 May 2013
top