Prof. Dr. Dr.med. Klaas Enno Stephan

 

Main Goals, Keywords

Translational neuromodeling: Developing computational models of brain (dys)function as tools for clinical applications (diagnostics and treatment prediction).

Group Members

1 professor,1 senior physician, 7 postdoctoral fellows, 5 PhD students, 1 technician, 2 administrators.

Previous and Current Research

Our goal is to establish mathematical models that infer subject-specific mechanisms of brain disease from non-invasive measures of behaviour and neuronal activity.

These models aim to quantify both physiological and computational principles that underlie (mal)adaptive cognition, such as aberrant learning and decision-making, in individual subjects.

The long-term goal is to use these models for a mechanistic re-definition of psychiatric and neurological diseases, leading to pathophysiologically interpretable diagnostic classifications and individual treatment predictions.

Techniques and Equipment

Techniques: statistical parametric mapping (SPM) computational modelling, dynamic causal modeling, fMRI, EEG, MEG.

Equipment: 3T & 7T fMRI scanners, 2x 128 channel EEG systems, behavioural lab, neurophysiological lab (TMS/tDCS), pharmacological lab, high-performance computer cluster, research clinic for patient studies.

Selected Lectures, Seminars or Colloquia

http://www.biomed.ee.ethz.ch/research/tnu/teaching

Selected Publications

• Brodersen, K.H., Schofield T.M., Leff A.P., Ong C.S., Lomakina E. I., Buhmann J.M. Stephan K.E. Generative Embedding for Model-Based Classification of fMRI Data. PLoS Computational Biology 7: e1002079 (2011).
  
• Den Ouden, H.E.M., Daunizeau, J., Roiser, J.P., Friston, K.J., Stephan, K.E. Striatal prediction error modulates cortical coupling. Journal of Neuroscience 30: 3210-3219 (2010).
  
• Stephan, K.E., Penny, W.D., Daunizeau, J., Moran, R.J., Friston, K.J. Bayesian model selection for group studies. NeuroImage 46: 1004-1017 (2009).

Funding

René and Susanne Braginsky Foundation, European Union FP-7, SystemsX.ch, NCCR "Neural Repair and Plasticity".

URL

http://www.biomed.ee.ethz.ch/research/tnu