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Dr. Bernd Wollscheid

 

Wollscheid_web
NCCR Neuro Center for Proteomics
Institute for Molecular Systems Biology

Wolfgang-Pauli-Strasse 16
8093 Zurich

Tel. +41 44 633 3684
Fax +41 44 633 1051

bernd.wollscheid@imsb.biol.ethz.ch

Main Goals, Keywords

Dr. Bernd Wollscheid and his research group are focusing on the development of a qualitative and quantitative understanding of the cellular surfaceome as a complex information gateway to the microenvironment. Further information about our research topics can be found here: Google Scholar / PubMed.


Keywords:

Systems Biology, Surfaceome Biology, Biomedical Proteomics, Quantitative Mass Spectrometry

Group Members

1 group leader, 1 PostDoc, 4 PhD students, 1 project/lab manager

Previous and Current Research

The molecular composition and dynamic organization of the plasma membrane (PM) determines how a cell can interact with its environment at any given moment. Cell surface proteins are crucial for cell-cell communication, interaction with pathogens, binding of chemical messengers, and responding to environmental perturbations. Alterations in the PM protein composition, as a result of a disease may well define phenotypic and functional differences between normal, and for example tumour cells. Cell surface proteins can be markers of disease and are potential targets for pharmaceutical intervention. The goals of our research group are:

In order to achieve these goals, we are utilizing state-of-the-art quantitative chemoproteomic tools in combination with fluorescence activated cell sorting technology, molecular imaging techniques and bioinformatic tools.

Future Projects

Please contact me (wbernd@ethz.ch) directly for details about these projects.

Techniques and Equipment

Our group is tightly integrated in the Institute for Molecular Systems Biology (IMSB), the NCCR Neuro and the Swiss Systems Biology initiative SystemsX. The ETH Zurich, Hönggerberg campus offers state-of-the art facilities for quantitative proteomics, computational analysis of large datasets, advanced light and electron microscopy, high-throughput, image-based RNAi and chemical compound screening.

Selected Publications

Funding

Swiss National Science Foundation (SNF), Swiss Commission for Technology and Innovation (CTI), SystemsX.ch, Agilent technologies, Roche

URL

http://www.imsb.ethz.ch/researchgroup/wbernd

 

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