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Dr. Jan Klohs

 

Jan_Klohs_web
Institute for Biomedical Engineering
University of Zurich and ETHZ
AIC – ETH HCI D426



Wolfgang-Pauli-Str. 10
8093 Zurich, Switzerland


Tel. +41 44 633 7629
Fax +41 44 633 1187

klohs@biomed.ee.ethz.ch

Main Goals, Keywords

Our research aims at studying pathophysiology in the brain with non-invasive imaging techniques. A major scientific focus is cerebral ischemia, where we are interested to learn how inflammatory processes after cerebral ischemia partake in blood-brain barrier impairment, hemorrhagic transformation and secondary tissue damage. To this end, we employ techniques like near-infrared fluorescence imaging and magnetic resonance imaging, molecular imaging probes, experimental models of cerebral ischemia, genetic mouse models and pharmacology.

Keywords: Stroke, optical imaging, magnetic resonance imaging, blood-brain barrier, thrombosis, mouse models of brain disorder

Group Members

1 group leader, 1 PhD student

Previous and Current Research

Future Projects

In vivo imaging studies with experimental models of cerebral ischemia to investigate how neutrophils mediate blood-brain barrier impairment, hemorrhagic transformation and thrombosis after focal cerebral ischemia.

Techniques and Equipment

The imaging studies will be done under the auspice of the group of Prof. Markus Rudin at the Animal Imaging Center (AIC). The equipment comprises two high-field MRI systems (4.7T and 9.4T), planar and near-infrared fluorescence imaging systems and tomographs. Surgical techniques will be used in animal models of cerebral ischemia.

Selected Publications

Funding

Swiss National Science Foundation

http://www.biomed.ee.ethz.ch

 

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© 2014 ETH Zurich | Imprint | Disclaimer | 13 May 2013
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